INFORMS Workshop on Data Science is a premier research conference dedicated to developing data science theories, methods, and algorithms to solve challenging and practical problems that benefit business and society at large. The workshop invites innovative data science research contributions that address business and societal challenges from the lens of statistical learning, data mining, machine learning, and artificial intelligence. The workshop invites original research addressing challenges in marketing, finance, and supply chain applications to problems in healthcare, energy, cybersecurity, social network services, privacy, credibility, etc. Contributions on novel methods may be motivated by insightful observations on the limitations of existing data science methods to address practical challenges, or by studying entirely novel data science problems. Research contributions on theoretical and methodological foundations of data science, such as optimization for machine learning and new algorithms for data mining, are also welcome.